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Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation. Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. Large-scale analysis of CRISPR/Cas9 cell-cycle knockouts reveals the diversity of p53-dependent responses to cell-cycle defects. An orthogonal tyrosyl-tRNA synthetase/tRNA pair from a thermophilic bacterium for an expanded eukaryotic genetic code. Site-specific incorporation of epsilon- N-crotonyllysine into histones. Ultradeep lysine crotonylome reveals the crotonylation enhancement on both histones and nonhistone proteins by SAHA treatment. Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Functions and mechanisms of lysine crotonylation. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.
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EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis. Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1). Molecular pathways regulating mitotic spindle orientation in animal cells.
#JINKE MARINA MEANING PLUS#
TIP150 interacts with and targets MCAK at the microtubule plus ends. Tracking the ends: a dynamic protein network controls the fate of microtubule tips.
#JINKE MARINA MEANING CODE#
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.
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Dynein tethers and stabilizes dynamic microtubule plus ends. The extracellular matrix guides the orientation of the cell division axis. Dynamic microtubules lead the way for spindle positioning. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Molecular architecture of the kinetochore-microtubule interface. These findings delineate a general signaling cascade that integrates protein crotonylation with accurate spindle positioning for chromosome stability in mitosis.Ĭheeseman, I. Real-time imaging of chromosome movements in HeLa cells expressing genetically encoded crotonylated EB1 revealed the importance of crotonylation dynamics for accurate control of spindle orientation during metaphase–anaphase transition. Mechanistically, TIP60 crotonylation of EB1 at Lys66 forms a dynamic link between accurate attachment of astral microtubules to the lateral cell cortex defined by NuMA–LGN and fine tune of spindle positioning. EB1 is a substrate of TIP60, and TIP60-dependent crotonylation of EB1 tunes accurate spindle positioning in mitosis. Here we delineated a new mitosis-specific crotonylation-regulated astral microtubule–EB1–NuMA interaction in mitosis. However, the regulatory mechanisms that couple astral microtubules dynamics to the spindle orientation remain elusive. Early studies indicate the essential role of the evolutionarily conserved Gαi/LGN/NuMA network in spindle positioning. Spindle position control is essential for cell fate determination and organogenesis. Nature Chemical Biology volume 17, pages 1314–1323 ( 2021) Cite this article Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis